How We Learned to Say NO

History of Discovery How We Learned to Say NO

What seest thou else In the dark backward and abysm of time —William Shakespeare First, there was Robert Furchgott.1 He simply and brilliantly demonstrated that endothelial cells play a pivotal role in relaxations evoked by acetylcholine in isolated arteries, and do so by activating muscarinic receptors of these cells. Actually, the quest for the understanding of the mechanism(s) underlying the...

Can we just say NO to sickle cell anemia?

How to say yes, no and maybe with visual cryptography

We present a version of a visual cryptography scheme in which a qualified set of participants is able to block the reconstruction of the secret.

Say NO to insulin

H. pylori mobilizes cells elicobacter pylori infects the gastric track of more than half of the human population and is associated with an increased occurrence of invasive gastric cancers. On page 249, Churin et al. explain how this widespread bug turns tumors metastatic by corrupting a growth factor receptor. H H. pylori infection mobilizes gastric epithelial cells (right) by activating c-Met....

Say NO to hypoperfusion!

AUTOREGULATION is defined as the capacity of an organ or tissue to maintain a constant blood flow in the face of a change in perfusion pressure, while metabolism is unchanged. Under normal physiological conditions, large proximal arteries contribute little to the total resistance of a particular vascular bed. However, when atherosclerosis causes a conductance artery to narrow so that over 70% o...